Profacgen offers professional high-throughput GPCR screening service for the identification of potential GPCR-targeting drugs. G protein-coupled receptors (GPCRs) are also known as seven-transmembrane domain receptors. They are only found in eukaryotes. Because of their extensive involvement in cell signal transduction, GPCRs have become important drug targets. Nearly 40% of modern drugs are GPCR-targeted, and 20% of top the 50 best-selling drugs are GPCR related.

GPCRs are found in yeast, choanoflagellates, and animals. Ligands that bind and activate GPCRs include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and range from small molecules, peptides to large proteins. The signal transduction is initiated by ligand binding to GPCR.